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1、Alzheimers Disease阿爾茨海默癥 Ronald Wilson Reagan羅 納 德 威 爾 遜 里 根第 40任 （ 第 49-50屆 ） 美 國 總 統(tǒng) president “ I know Im on my way to the twilight. I know theres always a bright dawn ahead of the United states. Thank you, my friends. May God bless you forever.” brief introduction01 PathogenyTreatment03 Clinical

2、 manifestation02 Other04Catalog brief introduction1 What?Alzheimers disease (AD) is a progressive neurodegenerative disorder .臨床癥狀Clinical symptom記憶障礙dysmnesia失語aphasia失認agnosia執(zhí)行功能障礙executive dysfunction癡呆dementiaThe disease usually begins after age 60, and risk goes up with age. Two types Alzheime

3、rs disease(AD) 65 years old senile dementia(SDAT)65 years old NameIn 1906,AD is named by Dr. Alois Alzheimer, a German doctor. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps. Scientists also have found other brain chang

4、es in people with AD.Nerve cells die in areas of the brain that are vital to memory and other mental abilities. Clinical manifestation2 Clinical manifestation 期期期death1-3 years 2-10 years 8-12 yearsMild dementia Moderate dementia Severe dementiaMore women than men 7:54:6 Disease for up to 10-20 year

5、s Degradation of memory and cognition William Utermohlen的 自 畫 像 Degradation of memory and cognition William Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited time available to retain memory and better under

6、stand himself through self portraits. William insisted the 5 New Year paintings self portrait, until completely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait became more and more abstract (pictured above)

7、. Degradation of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr. Bruce Miller, a neurologist. His work b

8、ecame more abstract, may be the parietal function damaged, causing blindness. What kind of changes have occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia. PathogenyTreatment3 Pathogenesis hypothesis of AD PathogenyAbnormal amyloid beta cell d

9、eposition in neurons Abnormal phosphorylation of tau proteinvs Beta amyloid (blue curve) and Tau protein (orange curve) Research papers published in recent 30 years Treatment increase the concentration of acetylcholine (Ach) in the brain promoting survival of cholinergic neurons in the brain or improving their nerve conduction function reducing the production or promoting degradation of beta amyloid Other4 Still AliceFilm The film tells the story of Alice Howland in seriously AD but still strong and brave .The film won the eighty-seventh Oscar award The NotebookMemories of Tomorrow